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Cells are less capable of withstanding toxic xenobiotics in the absence of Nrf2 Nrf2-null mice are sensitive to a range of stressors, including hyperoxia, acetaminophen, benzo[ a ]pyrene, butylated hydroxytoluene, diesel exhaust fumes, 7,12-dimethylbenz[ a ]anthracene, nitrosamine, and tobacco smoke [175–177]